The overarching goal of NAPI is to provide one nationally-coordinated expertise platform for proteomics research and knowledge transfer in Norway. NAPI is therefore involved in a diverse range of scientific projects; several NAPI partners carry out their own research activities, whilst NAPI core facilities serve scientists from across Norway who are involved in many different research fields. You can read more about some of these research activities here.
The techniques described below can be provided as a service for your research project. Some techniques are available at multiple NAPI nodes, whilst others are well-established at specific nodes. If you would like to discuss a new project, you can use our contact page to either make a general enquiry or contact a specific node directly. Researchers outside of Norway who are interested in working with our partners should also feel free to contact the NAPI project leader or administrative manager.
All services can include sample preparation (e.g. in-gel or in-solution protein digestion and peptide chromatography) as well as data analysis support, if required.
Users who publish MS data generated in collaboration with a NAPI core facility should acknowledge the core facility in the relevant manuscript. A template acknowledgements text is available here.
All NAPI core facilities have extensive experience in protein identification by mass spectrometry.
NAPI provides state-of-the-art expertise, methods and technology in quantitative proteomics.
Analysis of post-translational modifications (PTMs)
Post-translational modifications (PTMs) play vital roles in signaling pathways and, consequently, in regulating cell function. PTM analysis is therefore one of the most important tasks in proteomics.
Analysis of protein complexes/protein-protein interactions
Many of the functional units that control cell function are complexes that consist of multiple proteins.
Epigenetic/epitranscriptomic modifications in DNA and RNA play diverse and important roles in regulating cell behaviour. The systems-wide study of such modifications is referred to as modomics.
Metaproteomics exploits the power of high performance MS to investigate the complete set of proteins expressed by a microbial community within a particular niche.
One major challenge in current proteomics is efficient and reliable data analysis.