Metaproteomics exploits the power of high performance MS to investigate the complete set of proteins expressed by a microbial community within a particular niche.
This field is capable of generating new understanding of cooperative microbial actions in nature, such as in biomass conversion or in food and feed digestion. This also holds true for the complex interplay between the human gut and the gut microbiome.
Metaproteomics is one of several meta-omic methodologies used to study mixed microbial communities and define microbiomes. Unlike RNA analysis and metagenomics techniques, MS-based metaproteomics is able to provide quantitative information about which proteins are expressed within a sample, and by which member in the microbial community. This technology is booming due to today’s possibilities for genome reconstruction from metagenomics data, which in turn provides the basis for metaproteomic work of unprecedented depth, generating ground-breaking phenotypic insights at the community level.
All metaproteomics projects are currently performed at the NAPI node at NMBU, who have extensive experience in this field.